Hermosillo is a Spanish surname. Notable people with the surname include:
Carlos Hermosillo (born 1964), Mexican footballer Carmen Hermosillo (died 2008), American writer and poet Jaime Humberto Hermosillo (1942–2020), Mexican film director Mayra Hermosillo (born 1987), Mexican actress and filmmaker Michael Hermosillo (born 1995), American baseball outfielder Víctor Hermosillo y Celada (born 1939), Mexican politician