Gaines may refer to:
Places United States Gaines, Michigan, a village Gaines Township, Genesee County, Michigan, a civil township in which the above village is located Gaines Township, Kent County, Michigan, a charter township Gaines, New York, a town Gaines Township, Tioga County, Pennsylvania Gaines, West Virginia, an unincorporated community
People Gaines (surname) Gaines A. Knapp (1848–1918), American politician