Hepple is a surname. Notable people with the surname include:
Alan Hepple (born 1963), Canadian ice hockey player Anne Hepple (1877–1959), British writer Bob Hepple (1934–2015), South African academic Cameron Hepple (born 1988), Bahamian footballer Edward Hepple (1914–2005), Australian actor and screenwriter George Hepple (1904–1997), English fiddler Harry Hepple (born 1983), English actor Norman Hepple (1908–1994), English portrait painter, engraver and sculptor Robert Hepple (1898–1970), English footballer