Hennequin is a French surname. Notable people with the surname include:
Alfred Hennequin (1842–1887), Belgian dramatist Benjamin Hennequin (born 1984), French weightlifter Daniel Hennequin (born 1961), French physicist Denis Hennequin (born 1958), French businessman Emile Hennequin (1859–1888), a French philosopher Philippe-Auguste Hennequin (1762–1833), French painter Victor Hennequin, French medium Paul Hennequin (born 2002), French cyclist
See also Jean de Luxembourg (1400-1466), known as Hennequin Point Hennequin, headland of Antarctica