Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer research.
List of cell lines
Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53 Tumorigenic in mice Metastasis potential Reference External links 600MPE Invasive ductal carcinoma + – – Cellosaurus AMJ13 Invasive ductal carcinoma Primary Yes Yes No - - Cellosaurus AU565 Adenocarcinoma – – + – Cellosaurus BT-20 Invasive ductal carcinoma Primary No No No Yes Yes Cellosaurus BT-474 Invasive ductal carcinoma Primary Yes Yes Yes Yes Yes Cellosaurus BT-483 Invasive ductal carcinoma + + – Cellosaurus BT-549 Invasive ductal carcinoma – – + Cellosaurus Evsa-T Invasive ductal carcinoma, mucin-producing, signet-ring type Metastasis (ascites) No Yes ? Yes ? CellosaurusHCC 1137 HCC 1954 HCC 38 Hs578T Invasive ductal carcinoma Primary No No No Yes No Cellosaurus HTB-26 MCF-7 Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes No No (wild-type) Yes (with estrogen supplementation) Cellosaurus MDA-MB-231 Adenocarcinoma Metastasis (pleural effusion) No No No Yes Yes Cellosaurus SkBr3 Invasive ductal carcinoma Metastasis (pleural effusion) No No Yes Yes No Cellosaurus T-47D Invasive ductal carcinoma Metastasis (pleural effusion) Yes Yes No Yes Yes (with estrogen supplementation) Cellosaurus UACC-3199 ZR-75-1 Invasive ductal carcinoma Cellosaurus
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