John Kantakouzenos, Cantacuzene or Cantacuzenus () can refer to:
John VI Kantakouzenos (c. 1292 – 1383), Byzantine emperor and historian John Kantakouzenos (sebastos) (died 1176), Byzantine general John Kantakouzenos (Caesar) (fl. 1185/86), brother-in-law of Emperor Isaac II Angelos John Kantakouzenos (despot) (fl. c. 1342 – 1380), Byzantine prince John Kantakouzenos (pinkernes) (fl. 1244–1250), Byzantine aristocrat John Kantakouzenos of Novo Brdo (c. 1435 – 1477), Greek-Serbian nobleman