3-Bromobenzaldehyde is an isomer of bromobenzaldehyde. It is a colorless viscous liquid.
Synthesis 3-Bromobenzaldehyde can be prepared from 3-nitrobenzaldehyde.
To 1,2-dichloroethane (1,2-dichloroethane: 143.8 g, 1-bromo-2-chloroethane: 60.5 g, 1,2-dibromoethane: 4.8 g) recovered from Example 2 was added fresh 1,2-dichloroethane (41.5 g), and 98% aluminum chloride (0.65 mol, 88.6 g) was mixed. Into this was blown chlorine (0.25 mol, 17.8 g) at °C., and 97% benzaldehyde (0.50 mol, 54.6 g) was added over 1 hour at 40 °C. After bromine (0.30 mol, 48.0 g) was added dropwise to this mixture over 2 hours at 40 °C., the resulting mixtures were stirred for 2 hours at that temperature. The post-treatment was carried out by the similar procedure to that in Example 1. As a result, 83.1 g of 3-bromobenzaldehyde were obtained.https://prepchem.com/3-bromobenzaldehyde/
Patents:Roger A. Sheldon, et al. (1977 to Shell USA Inc).Shinichi Matsuura & Osamu Miyano, (1990 to Toso Organic Chemical Co Ltd).
Application SNDRI Application patent (PC9839278):James P. Beck, Mark A. Smith, Matt A. Curry, M. A. Aryl- and heteroarylsubstituted tetrahydroi-soquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin. WO2001032625 (2001 to Du Pont Pharmaceuticals Company).Bruce F Molino, Marlene Cohen, Barry Berkowitz, WO2006058016 (Amr Technology Inc).
See also 4-Bromobenzaldehyde
References