Seneca is a given name and an Italian surname which may refer to:
Given name Seneca Lassiter (born 1977), American former middle-distance runner Seneca M. Dorr (1820–1884), American lawyer, judge, politician and President of the Vermont Senate Seneca Paige (1788–1856), American-born businessman and political figure in Canada East Seneca Ray Stoddard (1844–1917), American landscape photographer Seneca Wallace (born 1980), American National Football League quarterback
In fiction Seneca Beaulac, from the American daytime soap opera Ryan's Hope Seneca Crane, in The Hunger Games novel by Suzanne Collins and the film adaptation
Surname Seneca the Elder (54 BC – 39 AD), Roman orator and writer, father of the Stoic philosopher Seneca Seneca the Younger (c. 4 BC – AD 65), Roman Stoic philosopher, statesman, and dramatist Isaac Seneca (1874–1945), American football halfback, first Native American selected All-American Joe Seneca (1919-1996), American actor and songwriter Robert Seneca (died 1931), American politician and merchant