Francis Kane may refer to:

Francis Kane (ice hockey) (1923–2016), Canadian ice hockey player Francis Fisher Kane (1866–1955), American lawyer Francis J. Kane (born 1942), American prelate of the Roman Catholic Church Francis X. Kane (1918–2013), American space planner and engineer Harold Robbins (1916–1997), American author born as Francis Kane

See also Frank Kane (1895–1962), Major League Baseball outfielder Magenta (DC Comics), a supervillain whose real name is Frances Kane