SL2 may refer to:
Art and entertainment SL2 (musical group), British breakbeat hardcore group Stuart Little 2, a 2022 film
Maths and science the mathematical structure SL2(F), a special linear group Special linear Lie algebra SL2 RNA, a non-coding RNA involved in trans splicing in lower eukaryotes Skylab 2 (SL-2), a NASA space mission
Technology and transport Leicaflex SL2, a mechanical reflex camera Leica SL2, a mirrorless digital camera Canon EOS 200D, or Rebel SL2, a digital reflex camera Schütte-Lanz SL2, an airship used in WWI SL2, car in the Saturn S series SL2 (MBTA bus), Boston bus line Skylab 2 (SL-2), a NASA space mission London Buses route SL2
Other uses SL postcode area, the Slough postal region covering Farnham, Great Britain Situational Leadership II, a leadership theory developed by Paul Hersey Super League Greece 2 Greece's 2nd Division football championship