Slatkin is a surname. Notable people with the surname include:
Felix Slatkin (1915–1963), American classical violinist and conductor Harry Slatkin (born 1960), American businessman Leonard Slatkin (born 1944), American conductor and composer Daniel Slatkin (born 1994), American film composer Montgomery Slatkin, American biologist Nora Slatkin (born 1955), United States Assistant Secretary of the Navy (Research, Development and Acquisitions) and Executive Director of the Central Intelligence Agency Reed Slatkin (born 1949), American fraudster