George Gillespie (1613–1648) was a Scottish theologian.
George Gillespie may also refer to:
George Alexander Gillespie (1872–1956), Ontario politician George Lewis Gillespie Jr. (1841–1913), Medal of Honor recipient George Gillespie (footballer) (1859–1900), Scottish footballer (Rangers FC, Queen's Park FC and Scotland) George D. Gillespie (1810–1909), bishop of Western Michigan in the Episcopal Church