Wortham is a surname. Notable people with the surname include:
Barron Wortham (born 1969), American football player Cornelius Wortham (born 1982), American football player Gus Sessions Wortham (1891–1976), American businessman John Lee Wortham (1862–1924), American businessman and politician Michael Wortham (born 2002), American football player Rich Wortham (born 1953), American baseball player Stanton Wortham, American academic