Ragusa is a surname. Notable people with the surname include:
Antonino Ragusa, (born 1990) Italian footballer Carmine Ragusa, fictional character from "Laverne & Shirley" Cinzia Ragusa (born 1977), Italian water polo player Eleonora Ragusa (1861–1939), also known as Kiyohara Tama, Kiyohara Otama, or Ragusa Tama, Japanese painter Kym Ragusa (born 1966), American writer and film director Vincenzo Ragusa (1841–1927), Italian sculptor