Değirmendere is a Turkish place name meaning "mill river" and may refer to:
Places Değirmendere, Alanya, a village in Alanya district of Antalya Province Değirmendere, Amasya, a village in the central district of Amasya Değirmendere, Balya, a village Değirmenderesi, Bolu, a village in the central district of Bolu Province Değirmendere, Ceyhan, a village in Ceyhan district of Adana Province Değirmendere, Çorum, a village in the district of Çorum Değirmendere, Ergani, a village Değirmendere, Gölcük, a former town and modern quarter in Gölcük district of Kocaeli Province Değirmendere, İspir, a village in the district of İspir Değirmendere, Mersin, a village in Toroslar district of Mersin Province
Other uses TCG Değirmendere (A-576), a tugboat of the Turkish Navy