Leftwich is an English language toponymic surname. It derives from Leftwich in Cheshire, England, which was named for Leoftæt, a female name, and "wic" (in Cheshire, "saltworks").
Notable people with the surname include:
Adrian Leftwich (1940–2013), South African anti-apartheid activist and academic Benjamin Francis Leftwich (born 1989), English singer-songwriter Brad Leftwich (born 1953), American fiddler and banjoist Byron Leftwich (born 1980), American football player Debbe Leftwich, American politician Jabez Leftwich (1765–1855), American politician Jim Leftwich (1944–2020), Australian Aboriginal bishop Joel Leftwich (1760–1846), American planter and politician John W. Leftwich (1826–1870), American politician Joseph Leftwich (1892–1983), English writer, poet, critic and translator Keith Leftwich (1954–2003), American politician Lloyd Leftwich (1832–1918), American politician Phil Leftwich (born 1969), American baseball player William Leftwich (c. 1737-1820), Lieutenant Colonel of the Continental Army William G. Leftwich, Jr. (1931–1970), United States Marine Corps officer
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