Loftis is a surname. Notable people with the surname include:
Curtis M. Loftis, Jr. (born 1958), American politician, businessman and philanthropist Dwight Loftis (born 1943), American politician Norman Loftis, American poet Robert Geers Loftis (born 1956), American diplomat Zenas Sanford Loftis (1881–1909), American missionary to Tibet