Thijssen, Thijsen and Thijsse are Dutch patronymic surnames. The common Dutch given name Thijs is a short form of Mathijs (=Matthew). Thijssen is particularly common in the Dutch provinces of North Brabant and Limburg. People with this surname include:

Thijssen (born 1961), Dutch painter and glass artist Felix Thijssen (1933–2022), Dutch novelist François Thijssen (died 1638), Dutch explorer of the south coast of Australia Frans Thijssen (born 1952), Dutch footballer Gerben Thijssen (born 1998), Belgian racing cyclist Henny Thijssen (born 1952), Dutch singer and music producer (born 1975), Dutch draughts player Leon Thijssen (born 1968), Dutch show jumper Lynn Thijssen (born 1992), Dutch volleyball player Maerten Thijssen (died 1657), Dutch admiral who later became a Swedish nobleman Nicole Thijssen (born 1988), Dutch tennis player Theo Thijssen (1879–1943), Dutch writer, teacher and socialist politician Walter Thijssen (1877–1943), Dutch rower Thijsen Ady Thijsen (born 1958), Aruban politician Cornelius Didrikson Thijsen Anckarstierna (1655–1714), Swedish admiral and noble born as Cornelis Thijsen Thijsse Jac. P. Thijsse (1865–1945), Dutch conservationist and botanist

See also Thyssen