De Nijs is a Dutch patronymic surname originating from the given name "Denijs" (=Denis). Notable people with this surname include:
E. Breton de Nijs, pseudonym of Rob Nieuwenhuys (1908–1999), Dutch writer of Indo descent Jack de Nijs (1941–1997), Dutch musician known by the name "Jack Jersey" Jan de Nijs (born 1958), Dutch cyclist Judith de Nijs (born 1942), Dutch swimmer, sister of Lenie Lenie de Nijs (1939–2023), Dutch swimmer, sister of Judith Rob de Nijs (born 1942), Dutch singer and actor
See also Denys Nijs Nijssen