American rapper Lil Wayne has released 286 singles including 19 promotional singles. Lil Wayne attained his first singles chart entry in 1999 as a featured artist on Hot Boys member Juvenile's single "Back That Azz Up", which peaked at number 19 on the United States Billboard Hot 100 and became a top ten hit on the Hot R&B/Hip-Hop Songs and Hot Rap Songs charts. Wayne later released his debut solo studio album Tha Block Is Hot in November 1999. Its title track and lead single, which features B.G. and Juvenile, reached number 72 on the Billboard Hot 100. Lights Out followed in December 2000 and produced the singles "Get Off the Corner", "Everything" and "Shine". "Way of Life", the lead single from Wayne's third studio album 500 Degreez, peaked at number 71 on the Hot 100 and became a top 20 hit on the Hot Rap Songs chart. In 2004, Wayne was featured on the single "Soldier" by American girl group Destiny's Child, which became his first top ten hit on the Hot 100 and enjoyed commercial success internationally.

Lil Wayne's fourth studio album Tha Carter featured the single "Go D.J.", which gave Wayne his first top 20 hit on the Hot 100 as a lead artist and was later certified platinum by the Recording Industry Association of America (RIAA). Tha Carter II followed in December 2005 and produced the platinum-certified singles "Fireman" and "Hustler Musik", which peaked at numbers 32 and 87 respectively on the Hot 100. The album Like Father, Like Son, a collaboration with rapper Birdman, featured four singles – "Stuntin' Like My Daddy", "Leather So Soft", "Know What I'm Doin'" and "You Ain't Know" – all of which entered the Hot R&B/Hip-Hop Songs chart. Wayne's critically acclaimed and commercially successful album Tha Carter III, released in June 2008, produced several hit singles. "Lollipop" became Wayne's first number-one single on the Billboard Hot 100 and was certified Diamond by the RIAA. "A Milli", "Got Money", and "Mrs. Officer" all hit the top 20 on the Hot 100 and attained platinum certifications from the RIAA. Wayne's rap rock album Rebirth was released in early 2010 and featured four singles. During this period, he also guested on a number of top ten hits, including T-Pain's "Can't Believe It", Kevin Rudolf's "Let It Rock", Jay-Z and T.I.'s "Swagga like Us" and Jay Sean's "Down", the latter of which gave Wayne his second number-one single on the Hot 100.

Following a nine-month prison sentence for criminal possession of a weapon, Wayne returned to the music business with the release of the album I Am Not a Human Being in September 2010. "Right Above It", featuring Young Money Entertainment signee Drake, became a top ten hit. Released in September 2011, Wayne's ninth studio album Tha Carter IV featured the Hot 100 top ten hits "6 Foot 7 Foot", "How to Love" and "She Will". Lil Wayne broke American rock and roll singer Elvis Presley's record for the most entries on the Billboard Hot 100 in September 2012, with the debut of Game's "Celebration" – in which he is featured – bringing Wayne's total number of entries on the chart to 109. Wayne released his tenth studio album I Am Not a Human Being II in March 2013; "Love Me" was the most successful of the album's four singles, peaking at number nine on the Hot 100 and selling one million digital copies. The album received mixed reviews from music critics, criticizing Wayne's use of censored words. In 2014, he released the single "Believe Me" featuring Drake. The single was met with acclaim many ranking Wayne's verse to be one of the best of that year, the single certified platinum by the RIAA. Tha Carter V was delayed twice because of his problems with Cash Money. In 2015 he released his 11th studio album Free Weezy Album which was a Tidal exclusive and was not released for sale. The album was promoted by the single "Glory" and received positive reviews.

After many delays, his twelfth album Tha Carter V was released on September 28, 2018.

As lead artist + List of singles as lead artist, with selected chart positions and certifications, showing year released and album name Title Year Peak chart positions Certifications Album US USR&B/HH USRap AUSPeak chart positions for singles in Australia: "Lollipop" and "Mirror": "Prom Queen": "Drop the World": "Right Above It": "How to Love": "No Frauds": "Uproar": "Gang Gang": "She Will": CAN FRA IRL NZ SWI UKPeak chart positions for singles in the United Kingdom: All except "A Milli", "Got Money", "Prom Queen", "Hot Revolver" and "On Fire": "A Milli", "Got Money", "Prom Queen", "Hot Revolver" and "On Fire": "Tha Block Is Hot" 1999 72 24 27 — — — — — — — Tha Block Is Hot "Respect Us" 2000 — — — — — — — — — — "Get Off the Corner" — 88 — — — — — — — — Lights Out "Hardball" 2001 — 68 — — — — — — — — Hardball (soundtrack) "Everything" — — — — — — — — — — Lights Out "Shine" 96 39 — — — — — — — — "Way of Life" 2002 71 23 16 — — — — — — — 500 Degreez "Where You At" — — — — — — — — — — "Get Something" 2003 — 97 — — — — — — — — "Bring It Back" 2004 — 47 — — — — — — — — Tha Carter "Go D.J." 14 4 3 — — — — — — — RIAA: 2× Platinum "Earthquake" — — — — — — — — — — "Fireman" 2005 32 15 10 — — — — — — — RIAA: 2× Platinum Tha Carter II "Hustler Musik" 2006 87 26 16 — — — — — — — RIAA: Platinum "Shooter" — 97 — — — — — — — — "I'm a D-Boy" — — — — — — — — — — "Stuntin' Like My Daddy" 21 7 5 — — — — — — — RIAA: Platinum Like Father, Like Son "Leather So Soft" — 41 16 — — — — — — — RIAA: Platinum "Know What I'm Doin'" 2007 — 58 22 — — — — — — — "You Ain't Know" — 56 — — — — — — — — "Gossip" — — — — — — — — — — The Leak "I'm Me" 97 63 — — — — — — — — RIAA: Platinum "Lollipop" 2008 1 1 1 32 10 196 28 3 39 26 RIAA: Diamond RIAA: 5× Platinum BPI: Platinum RMNZ: 2× Platinum Tha Carter III "A Milli" 6 1 1 — 54 — — — — 163 RIAA: 6× Platinum BPI: Platinum RMNZ: 2× Platinum "Got Money" 10 7 2 — 30 — — — — 184 RIAA: 3× Platinum "Mrs. Officer" 16 5 2 — — — — 12 — 57 RIAA: 3× Platinum BPI: Silver RMNZ: 3× Platinum "Prom Queen" 2009 15 — — 93 36 — — — — 112 RIAA: Platinum Rebirth "Hot Revolver" 33 — — — 54 — — — — 132 RIAA: Gold "On Fire" 62 54 25 — — — — — — 131 Rebirth "Drop the World" 18 — — 56 24 — 43 — — 51 RIAA: 5× Platinum BPI: Gold RMNZ: Gold "Knockout"201044 — — — — — — — — — RIAA: Platinum "I'm Single"82 38 23 — — — — — — — RIAA: Platinum I Am Not a Human Being "Right Above It"6 4 1 98 34 — — — — 37 RIAA: 4× Platinum BPI: Silver RMNZ: Gold "6 Foot 7 Foot"9 2 2 — 50 — — — — 71 RIAA: 7× Platinum BPI: Silver RMNZ: Platinum Tha Carter IV "John" 2011 22 19 12 — 90 — — — — — RIAA: 2× Platinum "How to Love" 5 2 2 58 20 97 — 24 67 48 RIAA: 6× Platinum BPI: Silver RMNZ: Platinum "She Will" 3 1 2 78 16 70 — — — 58 RIAA: 4× Platinum BPI: Gold RMNZ: Platinum "It's Good" 79 — — — — — — — — — "Mirror" 16 69 25 26 44 22 21 37 15 17 RIAA: 4× Platinum ARIA: Platinum BPI: Platinum RMNZ: Platinum "My Homies Still" 2012 38 20 16 — — — — — — — RIAA: Platinum I Am Not a Human Being II "No Worries" 29 7 7 — — — — — — — RIAA: 2× Platinum "Love Me" 2013 9 4 3 92 49 27 — — 72 44 RIAA: Diamond BPI: Gold RMNZ: 2× Platinum "Rich As Fuck" 38 11 8 — — — — — — — RIAA: 3× Platinum "Believe Me" 2014 26 7 2 — 97 — — — — 36 RIAA: 2× Platinum "Sucker for Pain" 2016 15 3 1 7 19 93 84 5 16 11 RIAA: 3× Platinum ARIA: Platinum BPI: Platinum RMNZ: 3× Platinum SNEP: Platinum Suicide Squad: The Album "Changed It" 2017 71 29 — — — 116 — — — — rowspan="2" "No Frauds" 14 8 5 58 25 43 71 — 50 49 ARIA: Platinum BPI: Silver MC: Gold RMNZ: Gold "Uproar" 2018 7 6 6 100 24 — — — — 99 RIAA: 2× Platinum MC: Gold RMNZ: Gold Tha Carter V "Don't Cry" 2019 5 4 — 50 19 — 29 — 64 28 RIAA: Platinum "Pullin'" — — — — — — — — — — Family Ties "Gimme Brain"(with Travis Barker and Rick Ross) — — — — — — — — — — "I Do It"(featuring Big Sean and Lil Baby) 2020 33 16 12 — 63 — — — — — Funeral "Shimmy" — — — — — — — — — — "Gang Gang" 2021 33 13 9 67 34 — 42 — — 56 RIAA: Platinum Hall of Fame "Lose" 86 31 — 38 61 — 20 35 — 18 All Over the Place "Lonely" 63 28 23 — 86 — — — — — "Feelin' Like Tunechi" 91 40 — — — — — — — — Trust Fund Babies "Ay!" 2022 82 — — — 57 — 92 — — 80 MC: Gold Mainstream Sellout "Kant Nobody" 2023 66 23 11 — — — — — — — I Am Music "Kat Food" — 34 — — — — — — — — Tha Fix Before Tha VI "Main One" — — — — — — — — — — "Brand New" — 34 — — — — — — — — Hit Me When U Leave the Klub: The Playlist "Presha" — 32 — — — — — — — — Welcome 2 Collegrove "Long Story Short" — 40 — — — — — — — — "Transparency" — 35 — — — — — — — — "Wassam Baby" 2024 — 47 — — — — — — — — rowspan="3" "Bless" — — — — — — — — — — "Baby Mad at Me" 2025 — 37 — — — — — — — — "—" denotes a recording that did not chart or was not released in that territory.

As featured artist 1999–2009 + List of singles as featured artist, with selected chart positions and certifications, showing year released and album name Title Year Peak chart positions Certifications Album US USR&B/HH USRap AUSPeak chart positions for featured singles in Australia: All except "Love in This Club Part II", "Forever", "Strange Clouds" and "Thank You": "Love in This Club Part II": "Forever": "Strange Clouds": "Thank You": "Only": "The Way I Are (Dance with Somebody)": CAN FRA IRL NZ SWI UKPeak chart positions for featured singles in the United Kingdom: General reference: "You": "Can't Believe It": "Revolver": "Miss Me": "Bow Chicka Wow Wow", "Motivation" and "I'm on One": "The Motto" and "Take It to the Head": "No New Friends": "Beware": "Backpack": "Thug Cry": "Truffle Butter": "Back That Azz Up" 1999 19 5 9 — — — — — — — RIAA: Gold RMNZ: Gold 400 Degreez "Bling Bling" 36 13 10 — — — — — — — Chopper City in the Ghetto "#1 Stunna" 2000 — 24 — — — — — — — — I Got That Work "I Know" — — — — — — — — — — Checkmate "Ride Out" 2001 — — — — — — — — — — Street Scriptures "Neva Get Enuf" 2002 — — — — — — — — — — A Girl Can Mack "Ain't It Man" 2003 — — — — — — — — — — Perfect Timing "Soldier" 2004 3 3 — 3 — 28 6 4 10 4 RIAA: Platinum ARIA: Gold BPI: Gold RMNZ: Platinum Destiny Fulfilled "Get Your Shine On" — 65 — — — — — — — —Fast Money "Neck of the Woods" — 71 — — — — — — — — "Hot Boys, Hot Girls" 2005 — — — — — — — — — — "Don't Trip" — 74 — — — — — — — — Glamorest Life "Gimme That" (Remix) 2006 15 5 — — — 45 26 — 30 23 RIAA: Platinum Chris Brown "Holla at Me" 59 24 15 — — — — — — — Listennn... the Album "You Know What" — 58 — — — — — — — — Director "Touch It or Not" — 62 — — — — — — — — Killa Season "Where da Cash At" — 73 — — — — — — — — Dedication 2 "Make It Rain" 13 6 2 — — — — 14 — — RIAA: Platinum Me, Myself & I "Hollywood Divorce" — — — — — — — — — — Idlewild "You" 9 1 — — — — — 25 — 45 RIAA: 4× Platinum BPI: Gold RMNZ: 2× Platinum MC: 2× Platinum Street Love "Money Ova Here" 2007 — — — — — — — — — — "We Takin' Over" 28 26 11 — 92 — — — — — RIAA: Platinum MC: Gold We the Best "Lock U Down" — — — — — — — — — — Liberation "Pop Bottles" 38 15 6 — — — — — — — RIAA: Platinum 5 * Stunna "9mm" — 66 — — — — — — — — The Greatest Story Ever Told "Duffle Bag Boy" 15 4 2 — — — — — — — RIAA: Platinum Supply & Demand "Uh-Ohhh!" — 69 — — — — — — — — The Mirror "Sweetest Girl (Dollar Bill)" 12 — — 28 14 — — 8 26 66 RIAA: Platinum MC: Gold RMNZ: Platinum Carnival Vol. II: Memoirs of an Immigrant "Screwed Up" — 71 — — — — — — — — Life Goes On "100 Million" — 69 — — — — — — — — 5 * Stunna "In the Hood" — — — — — — — — — — Street Medicine "My House" — — — — — — — — — — "Push" 2008 — — — — — — — — — — Insomniac "I Got My" — — — — — — — — — — Suppertime "Love in This Club Part II" 18 7 — 96 69 — — — — — RIAA: Platinum