Sapozhnikov (masculine, ) or Sapozhnikova (feminine, ) is a Russian surname, derived from the Russian word "сапожник" (cobbler/shoemaker/bootmaker). Notable people with the surname include:
Andrei Sapozhnikov (born 1971), Russian Soviet ice hockey player Anna Sapozhnikova (born 1997), Russian Paralympic athlete Nadezhda Sapozhnikova (1877–1942), Russian painter