Sir William Russell, 1st Baronet may refer to:
Sir William Russell, 1st Baronet, of Chippenham (died 1654), English politician Sir William Russell, 1st Baronet, of Wytley (c. 1602–1669), English politician Sir William Russell, 1st Baronet, of Charlton Park (1773–1839), Scottish physician
See also William Russell (disambiguation) Sir William Russell, 2nd Baronet