De Niro is an Italian surname. People with the surname include:
Drena De Niro (born 1967), American actress and film producer Grace Hightower De Niro (born 1955), American philanthropist, socialite, actress, and singer Raphael De Niro (born 1976), New York City real estate broker Robert De Niro (born 1943), American actor, director and producer Robert De Niro Sr. (1922–1993), American abstract expressionist painter Virginia De Niro alias Virginia Admiral (1915–2000), American painter and poet