Nompumelelo is a feminine Nguni name meaning "success". Notable people with the name include:
Nompumelelo Mhlongo (born 1961), South African politician Nompumelelo Mqwebu (born 1977), South African chef and author Nompumelelo Ngoma (born 1984), South African visual artist Nompumelelo Ntuli Zuma, former South African first lady Nompumelelo Maduna (born 1995), South Africa beauty pageant titleholder
Places Nompumelelo township of Hanover, Northern Cape Nompumelelo township of Buffalo City Metropolitan Municipality