di Rienzo, de Rienzo or Rienzo is a surname of Italian origin. Notable people with this name include:
Andre Rienzo (born 1988), Brazilian baseball pitcher for the Chicago White Sox Cola di Rienzo (c. 1313–1354), Italian politician and popular leader Franca di Rienzo, Swiss/Italian singer Libero De Rienzo (1977–2021), Italian film actor, director and screenwriter