Obeyesekere () is a Sinhalese surname. Notable people with the surname include:
Arjuna Obeyesekere, Sri Lankan puisne justice of the Supreme Court Donald Obeyesekere (1888–1964), colonial era legislator of Ceylon Forester Augustus Obeysekera (1880–1961), colonial era legislator of Ceylon Gananath Obeyesekere (1930–2025), Sri Lankan anthropologist, Professor of Anthropology at Princeton University James Peter Obeyesekere I (????–1880), colonial era legislator of Ceylon James Peter Obeyesekere II (1879–1968), Head Mudaliyar James Peter Obeyesekere III (1915–2007), Sri Lankan politician Solomon Christoffel Obeyesekere (1848–1927), colonial era legislator of Ceylon