Negussie (also Negusse, Negusie or Nigussie), meaning "King of", is a name of Ethiopian origin that may refer to:
Hailu Negussie (born 1978), Ethiopian marathon runner and 2005 Boston Marathon winner Abebech Negussie (born 1983), Ethiopian middle-distance runner Andualem Negusse (born 1985), Ethiopian footballer Yetnebersh Nigussie (born 1982), Ethiopian lawyer and disability rights activist
See also Negusie v. Holder, 2009 legal case at the United States Supreme Court regarding asylum