Loyola is a Basque surname. Notable people with the surname include:
Ángel Custodio Loyola (1926–1985), Venezuelan singer and composer Carlos Díaz Loyola (1894–1968), Chilean poet, known as Pablo de Rokha Ignacio Loyola Vera (born 1954), Mexican politician Ignatius of Loyola (1491–1556), Catholic saint and founder of the Society of Jesus José Inácio Candido de Loyola (1891–1973), Goan Catholic independence activist Juan Loyola (1952–1999), Venezuelan artist Margot Loyola (1918–2015), Chilean musician Martín Ignacio de Loyola (1550–1616), Franciscan friar and circumnavigator