Axford is an English surname. Notable people with this surname include the following:
Danny Axford (born 1975), English cyclist Emily Axford, American actress Graeme Axford, New Zealander human rights activist Ian Axford (1933–2010), New Zealand space scientist John Axford (born 1983), Canadian baseball player Kate Axford (born 1999), British cross-country runner Samuel M. Axford (died 1873), Michigan politician Thomas Axford (1894–1983), Sergeant in the Australian army