Axon is an English surname. Notable people with this surname include:
Annemarie Carney Axon (born 1973), American judge David Axon (1951–2012), British astrophysicist John Axon (1900–1957), English engine driver awarded the George Cross John Axon (actor) (1960–2008), English actor; grandson of John Axon the engine driver Rachael Axon (), English footballer Setta Axon (1870–1910), German-born British social worker William E. A. Axon (1846–1913), English librarian, antiquary, and journalist