Gaines is an English surname of Norman origin.

Notable people with the surname Gaines include:

Brian R. Gaines (born c. 1938), British systems scientist and engineer Cassie Gaines (1948–1977), American singer; backup singer for Lynyrd Skynyrd, sister of Steve Charles Gaines (writer) (born 1942), American writer and outdoorsman Charles Gaines (basketball) (born 1981), American basketball player Chip Gaines (born 1974), American actor, producer, television personality, contractor, and author Chris Gaines (1999–1999), fictional alter ego of American country singer Garth Brooks Chris Gaines (gridiron football) (born 1965), American football player Clarence Gaines (1923–2005), American basketball coach Corey Gaines (born 1965), American basketball player and coach Smokey Gaines (1940–2020), American basketball player David Gaines (racing driver) (1963–1990), American race car driver Earl Gaines (1935–2009), American blues singer Edmund P. Gaines (1777–1849), United States Army officer, brother of George Strother Ernest J. Gaines (1933–2019), African American author George Gaines (set decorator) (1933–1986), American art director George Strother Gaines (1784–1873), American leader in the Mississippi Territory, brother of Edmund Grady Gaines (1934–2021), American blues tenor saxophonist Greg Gaines (disambiguation), multiple people Grenville Gaines (1854–1922), American politician and lawyer Innis Gaines (born 1998), American football player Joanna Gaines (born 1978), American interior decorator, television personality, and author John Gaines (disambiguation), multiple people Jon Gaines II (born 1999), American football player Lloyd L. Gaines, (born 1911, disappeared 1939), American civil rights litigant Max Gaines (1894–1947), American comic book publisher, father of William Randal Gaines (born 1953), American politician Reece Gaines (born 1981), American basketball player Richard Gaines (1904–1975), American actor Riley Gaines (born 2000), American women's swimmer and activist Rowdy Gaines (born 1959), American swimmer Roy Gaines (1937–2021), American blues guitarist Ruth Gaines-Shelton (1872–1934), American educator and writer Sheldon Gaines (born 1964), American football player Sire Gaines (born 2006), American football player Stanley F. Gaines (1891–1950), American politician from Mississippi Stanley O. Gaines, American psychologist Steve Gaines (1949–1977), American musician, guitarist and songwriter for Lynyrd Skynyrd Wallace A. Gaines (1858–1940) American businessman, funeral director, and political figure Walter Lee Gaines (1881–1950), American dairy scientist William Gaines (disambiguation), multiple people