Guthridge is a surname. Notable people with the surname include:
Bill Guthridge (1937–2015), American basketball player and coach George Guthridge (born 1948), American writer Nehemiah Guthridge (1812–1878), Australian businessman Richard Charles Guthridge (1837–1934), Australian merchant seaman and farmer
See also Lake Guthridge, lake in Sale, Victoria, Australia Guthridge Nunataks, nunataks of Antarctica Guthridge, Missouri, a community in the United States