Aiono is both a surname and a given name. Notable people with the name include:
Aiono Nonumalo Sofara, Samoan chief Aiono Fanaafi Le Tagaloa (1932–2014), Samoan chief, historian, and writer Alex Aiono (born 1996), American singer and YouTuber James Aiono (born 1989), American football player Uluomato'otua ("Ulu") Saulaulu Aiono (born 1954), Samoan-born New Zealand technology entrepreneur, civic leader, and philanthropist