Menefee is a surname. Notable people with the surname include:
Christian Menefee (born 1988), American attorney and U.S. representative for Texas's 18th congressional district Curt Menefee (born 1965), American sports announcer David Menefee, American writer Hawkins Menefee (1945–1974), American politician from Texas Jock Menefee (1868–1953), American baseball player Maynard Menefee (1907–1993), American politician from Iowa Richard Menefee (1809–1841), American politician from Kentucky
See also Menefee Peak, mountain in Colorado, United States Menefee Formation, geological formation Menefee Shale, geological stratum