Makemie is a Scottish surname. It may refer to:
Francis Makemie (1658-1708), Ulster Scots clergyman considered the founder of Presbyterianism in the United States Anne Makemie Holden (1702-c. 1787/88), early American patriot, younger daughter of Rev. Francis Makemie Makemie Memorial Presbyterian Church in Snow Hill, Maryland Makemie Monument Park, formerly known as Pocomoke Farm, maintained in honor of Rev. Francis Makemie in Accomack County, Virginia, Makemie Park, Virginia