Flight 422 may refer to:
Air France Flight 422, a flight which crashed near Bogotá, Colombia, in 1998 Kuwait Airways Flight 422, a flight hijacked over the Gulf of Oman in 1988, leading to one of the longest skyjackings on record Flight 422, Kuwaiti television series based on the 1988 incident Merpati Nusantara Airlines Flight 422, a 1994 flight that overshot the runway at Indonesia's Achmad Yani International Airport