Aghajanyan, also transliterated as Aghajanian, (Աղաճանեան, Աղաջանյան) is an Armenian surname. Notable people with the surname include:
George Aghajanian (1932–2023), American neuroscientist Markar Aghajanyan (born 1965), Iranian Armenian footballer and manager Stepan Aghajanian (1863–1940), Armenian painter
See also Agajanian