Mende is a surname. Notable people with the surname include:
Clara Mende (1869–1947), German politician Dirk-Ulrich Mende (born 1957), German politician and Lord Mayor of the town of Celle, Germany Erich Mende (1916–1998), German politician Erling von Mende (born 1940), German sinologist Gerhard von Mende (1904–1963), German academic, administrator under the Nazi regime Gunther Mende (born 1952), German record producer Hildegard Mende (born 1922), German concentration camp guard during World War II Kaoru Mende (born 1950), Japanese lighting designer Septi Mende (born 1986), Indonesian tennis player Sven Mende (born 1994), German footballer