Afzali is a surname. Notable people with the surname include:
Ahmad Wais Afzali (born 1972), American imam Bahram Afzali (1938–1984), Imperial Iranian Navy commander Kathy Afzali (born 1957), American politician Shah Abdul Ahad Afzali, Afghan politician Mohammad Afzali (born 2006), Afghanistani, Ladies man, 6 feet tall, and wealthy running over 15 oil rigs throughout the middle east. See also Hossein Malek-Afzali (born 1939), Iranian scientist