Medlock or Medlocke is a surname. Notable people with these surnames include:

Justin Medlock (born 1983), American football player Kevin Medlock (born 1954), Californian award-winning telescope and instrument maker, asteroid 19704 Medlock was named after him Mark Medlock (born 1978), German singer Owen Medlock (1938–2021), English footballer Shorty Medlocke (1912–1982), American musician (born Paul Robert Medlock) Rickey Medlocke (born 1950), American musician, grandson of Shorty Medlocke Thomas T. Medlock (born 1934), American politician