Botello is a surname. Notable people with the surname include:
Ángel Botello (1913–1986), Spanish-Puerto Rican painter Feliciano de la Mota Botello (1769–1830), Argentine politician Javier Botello (born 1976), Spanish swimmer Jose Botello (born 1976), American soccer player José Alfredo Botello (born 1956), Mexican politician Kate Botello, American television personality Narciso Botello (c. 1815–1889), American politician