Acetophenone carboxylase () is an enzyme with systematic name acetophenone:carbon-dioxide ligase (ADP-forming). This enzyme catalyses the following chemical reaction
2 ATP + acetophenone + HCO3− + H2O + H+ 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate
The enzyme is involved in anaerobic degradation of ethylbenzene.
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