Kilbourne is a surname. Notable people with the surname include:
Ashe Kilbourne, DJ Amos Kilbourne, English footballer Charles E. Kilbourne (1872–1963), United States Army general Edward C. Kilbourne (1856–1959) Edwin D. Kilbourne (1920–2011), American scientist Ernest A. Kilbourne (1865–1928), American missionary James Kilbourne (1770–1850), American surveyor and politician Jean Kilbourne (born 1943), American writer Warren Kilbourne (1916–1967), American football player Wendy Kilbourne (born 1964), American actress