D-alanine—(R)-lactate ligase (, VanA, VanB, VanD) is an enzyme with systematic name D-alanine:(R)-lactate ligase (ADP-forming). This enzyme catalyses the following chemical reaction
D-alanine + (R)-lactate + ATP D-alanyl-(R)-lactate + ADP + phosphate
The product of this enzyme can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.
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