Holcocera guilandinae is a moth in the family Blastobasidae. It is found in the United States in southern Florida and on Bermuda.

The length of the forewings is 6.1-9.2 mm.

The larvae feed in the stem of Caesalpina bonducella and Garberia heterophylla.On the identity of Holcocera guilandinae (Busck, 1900) (Lepidoptera: Gelechioidea: Coleophoridae: Blastobasinae)

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