Lobe is a surname of German origin. Notable people with the surname include:
Bill Lobe (1912–1969), American baseball player and coach Jim Lobe (born 1949), American journalist Kārlis Lobe (1895–1985), Latvian collaborationist with the Nazis Mira Lobe (1913–1995), Austrian author Robert Lawrance Lobe (born 1945), American sculptor