α-seco-amyrin synthase () is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-seco-amyrin-forming). This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene alpha-seco-amyrin

The enzyme from Arabidopsis thaliana is multifunctional.

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