Deslys is a surname. Notable people with the surname include:

Charles Deslys (1821–1885), French writer Gaby Deslys (1881–1920) French dancer, singer, and actress Kay Deslys (1899–1974), British comedy actress in 1920s American films Lily Deslys, a stage name of Lili Damita (1904–1994), French actress