Leno is a surname. Notable people with the surname include:
Bernd Leno (born 1992), German footballer Dan Leno (1860–1904), English music hall comedian Jay Leno (born 1950), American comedian, actor, voice actor, writer, producer, and television host John Bedford Leno (1826–1894), English radical activist Mark Leno (born 1951), American politician Charles Leno (born 1991), American football player