La Salle, Lassalle, or de La Salle is a surname. Notable people with the surname include:
Adrien-Nicolas Piédefer, marquis de La Salle (1735–1818), a French writer and cavalry officer Antoine de la Salle (1385/86–1460/61), French courtier, educator and writer Antoine Charles Louis de Lasalle (1775–1809), French cavalry general during the French Revolution and Napoleonic Wars Bernard de la Salle ( 1360s), a French mercenary captain during the Hundred Years War Denise LaSalle (1939-2018), American singer Eriq La Salle (born 1962), American actor Ferdinand Lassalle (1825–1864), German-Jewish jurist and socialist political activist François Poulletier de la Salle (1719–1788), a French medical doctor and chemist Gadifer de la Salle (1340–1415), French soldier of Poitevine origin Horace His de la Salle (1795-1878), a French art collector Jean-Baptiste de La Salle (1651–1719), Patron saint of Teachers and Founder of Institute of the Brothers of the Christian Schools Joseph P. LaSalle (1916–1983), American mathematician known for the LaSalle invariance principle Lise de la Salle (born 8 May 1988), a French classical pianist Mick LaSalle (born 1959), movie critic for the San Francisco Chronicle Nicolas de la Salle (died 1710), French colonial governor René-Robert Cavelier, Sieur de La Salle (1643–1687), French explorer of North America